XMRV -we must not forget the Lessons of History

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>>>> 2 January 2011 <<<<
Editorship : j.van.roijen@chello.nl
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http://www.ukunote.com/?p=10011



Light of Sience




High degree of vigilance:
a possible new with the
HIV virus less dangerous




January 1, 2011



There are two previously known retroviruses can
infect humans and cause serious diseases: HIV
(AIDS virus) and HTLV (human T cell leukemia virus,
can cause T-cell lymphoma and T cell leukemia).

In recent years, also found a third infected human
retrovirus: XMRV (heterophile murine leukemia
virus-related virus), this virus may be associated
with prostate cancer and chronic fatigue syndrome
(CFS) related.

As might be suspected XMRV is a new virus HIV as
dangerous, XMRV’s found in the international
scientific community quickly caught a huge
response.

Twenty years, the research surrounding HIV, the
international community has formed a large strength
of the professional scientific research team.

XMRV and HIV belong to the retrovirus, the past
year, specializing in HIV, which had the world’s top
research institutions have the relevant research into
the XMRV become the main force of XMRV, related
research progress has been very rapid.


This year in September, the U.S. National Institutes
of Health (NIH) has organized a first international
XMRV seminar attracted 11 countries around the
world-renowned research institutions in 57 of 225
international delegates.

NIH’s Dean Collins (Francis Collins) personally
presided over the seminar and keynote speech, which
is rare in the history of the hospital, which is XMRV
has been unprecedented global attention as an
example.


XMRV first discovered in 2006 in men suffering from
prostate cancer tissue samples. Speculate as XMRV
virus and HIV, may be transmitted through blood
transfusion or exchange of body fluids.

July 2009, the United States invited by the NIH
Cancer Institute held a joint meeting internal and
external experts to discuss the XMRV infection on
public health.


In the October 8, 2009 the United States “Science
(Science)” A study published in the journal, the first
report of chronic fatigue syndrome (CFS) and the
potential relevance XMRV virus .

In this study, we found XMRV diagnosed in 67% of
CFS patients detected in the blood, but only 3.7% in
the blood cells of healthy individuals detected XMRV
of DNA.

Thesis of the article published in this study further
found that up to 98% of CFS patients, the virus can
be detected.


U.S. Department of Health and Human Services
(HHS) published the article of the month immediately
announced: HHS will support the assessment of
blood supply XMRV the potential risks of research
and development of standardized XMRV detection
method.

To this end, HHS has also established a special
inter-departmental “blood XMRV research group”, the
coordination of action.


As speculated XMRV and chronic fatigue syndrome
(CFS) may exist between the contact and may spread
through blood transfusion, blood transfusion in many
countries in Europe and America later authorities
have announced emergency measures, has been
indefinitely postponed or prohibited diagnosis
individual donations for the CFS.

Canada in early April this year announced a ban on
world’s first blood donation in patients with CFS. In a
very short time since the countries have announced
the ban, including New Zealand, Australia, the
United States, United Kingdom.


U.S. Food and Drug Administration (FDA), NIH and
Harvard Medical School on August 23, 2010 in the
“U.S. National Academy of Sciences (PNAS)”
published on the joint, the results support the above
“Science” magazine reports.

Although they found that not XMRV, but slightly
different sequence of another murine leukemia
virus-related virus PMV, but they belong in the
classification of hepatitis C retrovirus.



``````````````````````
~jan van roijen:
This statement is not correct!

XMRV does not belong to the
classification of hepatitis C;
it is a *Human GammaRetroVirus*.
``````````````````````


United States of leading experts in anti-retroviral
Coffin (John Coffin) Professor, XMRV in the general
population of the infection may be more worthy of
attention.

Previous study healthy people XMRV infection was
3.7%, if the data can be extended to the United
States, means that the United States alone, there
are nearly 1000 million people carry the pathogenic
potential of retroviruses.

As with HIV, XMRV cause illness or death in the past
few years or decades may be in a dormant state.

These have been infected but not disease may have
spread the virus’s ability, but their blood can not
limits. How to control such sources of infection, is a
more serious challenge. There is an urgent need for
energy is simple, rapid and accurate method to
detect XMRV.



U.S. NIH, FDA, Center for Disease Control and
Prevention (CDC) to take prompt action, the United
Abbott and other world-class diagnostic products
company, go all out for XMRV related diagnostic
method.

Sensitive trade surplus has been the development of
nucleic acid detection method, quantitative detection
of DNA or XMRV plasma RNA, under laboratory
conditions have been reported up to 100% accuracy
and no false positive or false negative.

XMRV has been established to the sensitive cell line
proliferation, the level of detection in single-copy
replication XMRV, and large-scale production XMRV
virus particles as antigen detection.

In addition, serological methods have been
established (such as ELISA, Western Blot, etc.) and
immunohistochemistry methods.

The next step is to shade a variety of representative
samples with reference material assembled into a
series of packages (panel), multiple testing in
multiple laboratories to test the platform
comparative analysis of the panel to determine the
standardized procedures of various detection
methods and various quality control indicators, for
eventual FDA approval, to meet the market demand.



Before and after 1984, the pathogen of AIDS in
humans and possible transmission route in some
preliminary results, the relevant administrative
departments to move slowly, leaving many countries
(including France, the United States, Germany and
other developed countries ), have appeared in the
tragic spread of AIDS through blood transfusion.


XMRV current research and found the beginning of
the HIV situation is similar. As XMR discovered not
long, the current study is far from adequate, the
results of different laboratories are sometimes
inconsistent or even conflicting.

The source of the virus and pathogenic mechanisms
are not yet established, it is with prostate cancer
and surviving the causal relationship between CFS
controversial.

But we must not forget the lessons of history must
not repeat the discovery of HIV at the beginning of
human mistakes. Must take timely and decisive
measures to prevent the manufacture of our hands
by another AIDS epidemic. With the progress of the
study may also have taken measures to require
appropriate adjustments.


XMRV momentum from the current study to see
estimated in a year or two will be able to draw
definitive conclusions.

If the XMRV really new pathogens, and humans will
be able to find effective prevention and control
methods.


CFS in the global average of 0.4% -1% incidence in
theory should also apply to China, which has never
been of great importance to CFS research. China is a
populous country, it must immediately take the
necessary action.












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