GcMAF -Promise & Pitfalls -ME/CFS

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GcMAF – The promise and the pitfalls


By Rutt


21.01.11




*Gcmaf is one of the most promising, if not the
most promising drug for ME/CFS this side of
ampligen and far cheaper than ampligen.


Dr. Cheney, Dr. Kenny de Meirleir and others are
running small-scale studies with this compound
which was found by its proprietor, Dr. Yamamoto to
eradicate HIV.


Dr. De Meirleir recently announced that the combo of
gcmaf and nexavir (an immune modulator) converted
a patient from XMRV sero-positive to -negative.

I have been in contact with multiple patients,
including one XMRV-pos whom has improved
significantly from this natural compound which
stimulates macrophage activity.



The questions that remain are:

1) which source out of the three (Yamamoto, Dr De
Meirleir, BGLI in the Netherlands) has the most
potency and contains 100% human derived material
– this question can only be answered by a truly
independent lab.


2) what is the true role of VDR status in predicting
treatment outcome and which lab has the accurate
results (currently redlabs Belgium seems to produce
conflicting results with Amy Yasko’s lab)


3) what role will the FDA play? Currently shipments
of BGLI gcmaf are being held up at customs, yet
patients are biting the bullet and ordering in hopes
their shipment will slip through the cracks. As if
patients haven’t been skewered financially enough.



In my own opinion, this drug holds so much promise
not only in terms of results but in terms of method
of action.

It triggers innate immunity so it is unlikely to lead to
viral resistance, superbugs, or the viral biofilms that
were announced in sciencedaily this morning.

Bacterial biofilms developed theoretically due to
rampant antibiotic use. Life will find a way, and
therapeutically we have a choice to try to beat the
bug into submission with WMDs like ARVs or bolster
our own immunity.


However, the caveat is, Ampligen theoretically was
supposed to stimulate our immunity to enable us to
win the war, and patients inevitably always relapsed
once they stopped the drug.


With that said, perhaps a combination of both routes
can cover the gamut, which may be why some
high-profile XMRV researchers are discussing testing
terrain therapies such as peptide T, gcmaf, nexavir,
and even stem cells in combination with HAART.


With XMRV, it is far more likely than with HIV, that
reservoirs are a primary issue because it is
slow-replicating.

Therapies such as interleukins have been used to
draw HIV out of latency with varying success.

XMRV researchers will likely need to consider the
problem of drawing virus out of latency (ie stem cells
since stem cell division equals viral replication) as
well as cutting the provirus (the viral DNA integrated
into our human DNA) with methods that mimic
restriction enzyme systems which remove foreign
viral DNA from our own DNA.

Leave the provirus in there and it may trigger
oncogenes, which may be why XMRV has been found
in prostate and breast cancer.


A somewhat overlooked risk with gcmaf is that XMRV
and HIV have been found in macrophages, so taking
a macrophage-stimulator is in theory a bit like giving
your crippled bodyguard steroids to take on the guy
that did the crippling. A logical fallacy if you will, but
results speak louder than funny-looking bodyguards.

Another thing is macrophages have been found in the
temporal lobes, so triggering latent retroviruses in
the brain may be a recipe for disaster.


In the end, gcmaf is but one way to attack the virus.
I just hope we get to find out what it can really do
before the powers that be decide to intervene
because its an unpatentable substance that happens
to achieve what billions of dollars of research into
HIV drugs has failed to achieve.*





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