Gluten & Gastrointestinal Symptoms -Without Celiac Disease

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>>>> 16 January 2011 <<<<
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Because many ME/CFS patients suffer from *Irritable
Bowel Syndrome* (IBS), this article may be of
interest.



Personal experience:

After a strong positive H2S Urine Test [PROTEA
Biopharma - see Co-Cure: http://bit.ly/f71l6r],

a severe bowel-dysbiosis was found with a
overgrowth of H2S and d/l lactate-producing bacteria.
Also found were several intolerances: gluten,
fructose and lactose.

Immediately after the gluten-, fructose-, lactose-free
diet, I became very sick with high fever and
night sweats; which was explained as detoxification
symptoms.

I'm still busy with a long antibiotic cure.



~jan van roijen




````````


http://bit.ly/fqkJ7l


AJG

The American Journal of
GASTROENTEROLOGY




Colon/Small Bowel


(11 January 2011)

doi:10.1038/ajg.2010.487


Gluten Causes Gastrointestinal
Symptoms in Subjects Without Celiac
Disease: A Double-Blind Randomized
Placebo-Controlled Trial


Jessica R Biesiekierski, Evan D Newnham, Peter M
Irving, Jacqueline S Barrett, Melissa Haines,
James D Doecke, Susan J Shepherd, Jane G Muir
and Peter R Gibson



OBJECTIVES:

Despite increased prescription of a gluten-free diet
for gastrointestinal symptoms in individuals who do
not have celiac disease, there is minimal evidence
that suggests that gluten is a trigger.

The aims of this study were to determine whether
gluten ingestion can induce symptoms in non-celiac
individuals and to examine the mechanism.

METHODS:

A double-blind, randomized, placebo-controlled
rechallenge trial was undertaken in patients with
irritable bowel syndrome in whom celiac disease was
excluded and who were symptomatically controlled
on a gluten-free diet.

Participants received either gluten or placebo in the
form of two bread slices plus one muffin per day with
a gluten-free diet for up to 6 weeks.

Symptoms were evaluated using a visual analog
scale and markers of intestinal inflammation, injury,
and immune activation were monitored.



RESULTS:

A total of 34 patients (aged 29–59 years, 4 men)
completed the study as per protocol.

Overall, 56% had human leukocyte antigen
(HLA)-DQ2 and/or HLA-DQ8.

Adherence to diet and supplements was very high.

Of 19 patients (68%) in the gluten group, 13
reported that symptoms were not adequately
controlled compared with 6 of 15 (40%) on placebo
(P=0.0001; generalized estimating equation).

On a visual analog scale, patients were significantly
worse with gluten within 1 week for overall
symptoms (P=0.047), pain (P=0.016), bloating
(P=0.031), satisfaction with stool consistency
(P=0.024), and tiredness (P=0.001).

Anti-gliadin antibodies were not induced. There were
no significant changes in fecal lactoferrin, levels of
celiac antibodies, highly sensitive C-reactive protein,
or intestinal permeability.

There were no differences in any end point in
individuals with or without DQ2/DQ8.


CONCLUSIONS:

*Non-celiac gluten intolerance* may exist, but no
clues to the mechanism were elucidated.



``````




To read this article in full you may need to log in,
make a payment or gain access through a site
license [http://bit.ly/fqkJ7l]





~~~~

Dr. Mikovits -Retrovirus Reaction

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>>>> 14 January 2011 <<<<
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http://bit.ly/hcYB09



bohemian.com

The Arts

01.12.11


review


Retrovirus Reaction

Dr. Judy Mikovits stirs up controversy in
neuroimmune disease community



By Leilani Clark


*If you've been sick for 10 years, 20 years, 30 years,
and you've been to all kind of doctors and you can't
seem to get well, these people are desperate to find
what might be the key to helping them,* says Tom
Klaber.

*For some of them, XMRV could be just the thing.*


Klaber, a principal at Santa Rosa consulting company
Bridge Medicine & Health, has been instrumental in
bringing Dr. Judy Mikovits to Sonoma County.

Mikovits is the lead author of a 2009 paper published
in Science Magazine showing that more than 70
percent of patients diagnosed with chronic fatigue
syndrome also tested positive for XMRV, a human
retrovirus discovered in 2006.

One of only three known retroviruses (HIV being
another), the discovery may hold the key to
unlocking the mysteries of many illnesses, including
prostrate cancer, fatigue, lymphoma, multiple
sclerosis and autism.


Like medical theatrics straight out of a Michael
Crichton novel, certain groups have challenged
Mikovits claim that strong associations can be made
between XMRV and cancer or other neuroimmune
diseases.

A study in England purported to find none of the
retrovirus in blood samples, a claim later discredited
when it was revealed that the researchers had used
an entirely different method of testing from the
original.


*[Mikovit's paper] really upset a lot of apple carts,*
says Klaber. *There were people with cherished
beliefs about the cause of chronic fatigue were not
happy. Ego, greed, prestige and power is as rampant
in academia as anywhere else.*


Klaber encourages anyone suffering from chronic or
debilitating illness to attend the public talk.

*Significant numbers of people have chronic illness
and just can't feel happy,* he says. *XMRV is
obviously playing a role for many of these people.*


Find out more about XMRV when Dr. Judy Mikovits
speaks on Monday, Jan. 17, at the Friedman Center.
4676 Mayette Ave. 2pm. Free. 707.396.5835.



Send a letter to the editor about this story
[http://bit.ly/i6nl7L]




~~~~

Dr. Mikovits dismayed about Private Conversation

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>>>> 13 January 2011 <<<<
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From: Jamie Deckoff-Jones

Re: [CO-CURE] med: XMRV+ve Patients & Retroviral Treatment



Dear Jan,

We all wish that this account was accurate, but
unfortunately it is not.

Here is a statement from Dr. Mikovits.

Would you please post?


Thank you,


Jamie Deckoff-Jones MD
Clinical Advsory Board
Whittemore Peterson Institute




``````


I am dismayed to read about a private conversation,
a portion of which has been taken out of context,
and disseminated on the internet.

My recollection is that the conversation was much
more measured than what is portrayed here.

In fact, the anecdotal response to antiretrovirals has
been mixed, though there have been some notable
successes.

The response to treatment, or lack thereof, is an
important piece of the puzzle.

I am not a clinician. I am a scientist. My enthusiasm
for antiretroviral drugs stems from (unpublished)
laboratory evidence that treatment with
antiretrovirals impacts the disease.

Although scientific convention generally requires not
discussing prepublication findings, the enormity of
the public health disaster ethically requires
suspension of these norms.

The WPI is committed to making any clinically
relevant information available. Our clinical advisory
board was formed to address this issue.

Our vision is to have a research group and clinical
group that interact to produce meaningful treatment
for patients as soon as possible.

We are doing everything in our power to open the
clinic to patients in the very near future. It is a
unique opportunity for true translational medicine,
bench to bedside to bench, and should further our
understanding of XMRV/HMRV infection in the most
direct way possible.

For the last year, I have been forced to respond to
clinical questions, because many patients have had
no one else to ask. We are making progress towards
providing physicians to answer questions about
treatment.



Judy A. Mikovits






``````````


Reference: Co-Cure http://bit.ly/gyC9xN



On Jan 7, 2011, at 6:15 PM, Jan van Roijen wrote:

> ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
> Send an Email for free membership
> ~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~
> >>>>> Help ME Circle <<<<
> >>>> 7 January 2011 <<<<
> Editorship : j.van.roijen@chello.nl
> ~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~:~
>
>
>
>
>
>
> Many thanks to Doctor Speedy from
>
> THE NICEGUIDELINES BLOG
>
> at: http://bit.ly/e8fuRn
>
>
> ~jvr
>
>
>
>
> ``
>
>
> http://on.fb.me/igjcnK
>
>
> XMRV positive patients
> respond to retroviral treatment!!
>
>
>
> by Jan Maverick
>
>
> Fryday 7 January 2011
>
>
>
>
> Xinnian a UK sufferer from Foggy Friends
> has given permission for me to post the
> following:
>
>
>
> *....I also spoke to Dr Mikovits for quite some time
> this evening regarding M.E patients that are
currently
> being treated for X.M.R.V.
>
>
>
> Here's roughly what she had to say:
>
>
> She knows of approx 20 human subjects tested
> positive for X.M.R.V being treated with
> anti-retrovirals and the results are astonishingly
> positive:
>
>
> 4 Patients, some from bedbound state - Now well
> and considering themselves FULLY recovered!
>
>
> 6 Patients 50% recovered - so far!
>
>
> 6-8 Patients 3-4 good days per week - so far!
>
>
> 2 Patients non-responsive (likely down to
> complications with Lymes)
>
>
>
>
> Dr Mikovits added that those recovering will just
> need extra time on the treatment until fully
> recovered.
>
>
>
> This is good news for all of us and it has left me
> trembling to think that one day, perhaps not in
> distant future, that I might be well again....*
>
>
> Amazing results and great news in my opinion, I
> hope you all agree!
>
>
>
> Jan x
>
>
>
>
>
> N.B. Please note than none of these
> patients are being treated by the WPI.
>
>








~~~~

a Reminder -Lost Voices....

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From: Gurli Bagnall





A REMINDER


Gurli Bagnall



Some months ago, I was given a precious gift. It
was a copy of:


*Lost Voices: from a hidden illness*


The book is beautifully presented and was collated
and published by Invest in ME.


I was so impressed, I acquired two more copies and
gave one to the local MS Society since they recognize
ME as neurological disease.

I keep the second copy on a table for visitors to look
through and also to lend to those who wish to read
it.

The third, I guard jealousy for this is MY copy.

I raise the issue now because it is clear that even
with the discoveries made during the course of the
last couple of years, we cannot afford to relax.

We still need to remind the public that this is a
serious disease which causes utter devastation in
the lives of its victims and their families.



Copies of this high quality production can still be
obtained from:


Invest in ME in the UK
www.investinme.org
http://bit.ly/gyu3CO (order form)
Telephone: 02380 251719 or 07759 349743



And in Australia from:

the Alison Hunter Memorial Foundation:
www.ahmf.org
http://bit.ly/efddFe (Book Order)

Contact Christine Hunter on:

chunter@ahmf.org
Telephone and fax: +61 2 9958 6285









~~~~

De Meirleir on Retrovirus

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http://bit.ly/gMONLg




Life as we know it

The newest research about living with Chronic
Fatigue Syndrome (CFS)/XMRV/HGRAD/fibromyalgia,
with personal observations (the most pertinent parts
of long articles will be highlighted for the reader)



Sunday, January 9, 2011


De Meirleir on Retrovirus


Retrovirus in European patients: De
Meirleir confirms NIH/FDA & WPI findings
(in FRENCH)



Study results will be shared at the Sept. 7
& 8 international XMRV conference



``````````


Google translation of article below



Discovery: a new virus
could cause chronic fatigue



Magazine - Health Sciences and Tues, August 24,



Researchers at the Vrije Universiteit Brussel (VUB)
and the Belgian company biotech *RED Laboratories*
are able to identify a new retrovirus in patients with
chronic fatigue syndrome, said Tuesday the VUB in a
statement.

These results corroborate a recent American
discovery.


U.S. researchers from the University of Nevada were
discovered in October 2009, the majority of patients
suffering from chronic fatigue syndrome were carriers
of a new retrovirus XMRV.

Before the Belgian study, the U.S. findings had been
confirmed by the Harvard Medical School and the
National Institute of Health (NIH).


Research conducted under the direction of Professor
De Meirleir (VUB) is a novelty because the virus has
been found in sick patients from across Europe.

Moreover, the immunological signature is comparable
to that of a patient with AIDS.


This new discovery will be presented on September 7
and 8 coming at a workshop of the National Institute
of Health in Washington.




``````````



Découverte: un nouveau virus
pourrait causer la fatigue
chronique





Magazine - Sciences et Santé mar 24 aoft



Des chercheurs de la Vrije Universiteit Brussel (VUB)
et de la société belge de biotechnologie "R.E.D.
Laboratories" sont parvenus B identifier un nouveau
rétrovirus chez les patients souffrant du syndrome de
fatigue chronique, a annoncé mardi la VUB dans un
communiqué.

Ces résultats corroborent une découverte américaine
récente.


Des chercheurs américains de l'Université du Nevada
avaient découvert, en octobre 2009, que la majorité
des patients souffrant du syndrome de fatigue
chronique étaient porteurs d'un nouveau rétrovirus
XMRV.

Avant l'étude belge, ces conclusions américaines
avaient déjB été confirmées par la Harvard Medical
School et par l'Institut national de la santé (National
Institute of Health).


La recherche menée sous la direction du professeur
De Meirleir (VUB) constitue une nouveauté car le
virus a été découvert chez des patients malades
issus de toute l'Europe.

Par ailleurs, cette signature immunologique est
comparable B celle d'un patient atteint du sida.


Cette nouvelle découverte sera présentée les 7 et 8
septembre prochains lors d'un workshop de l'Institut
national de la santé B Washington.





Source: http://bit.ly/hlv07t



Posted by CFS Facts






~~~~~~

XMRV -Host Range and Cellular Tropism

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http://bit.ly/egjKTy



Host range and cellular tropism of the
human exogenous gammaretrovirus XMRV.


Stieler K, Schulz C, Lavanya M, Aepfelbacher M,
Stocking C, Fischer N.


Institute for Medical Microbiology and Virology,
University Medical Center Eppendorf, Martinistrasse
52, 20246 Hamburg, Germany.



Abstract


Recently, the first human infection with an
exogenous gammaretrovirus (XMRV) was reported.

In its initial description, XMRV was confined to
prostate stromal fibroblasts, although subsequent
reports demonstrated XMRV protein expression in
prostate epithelial cells.

Most recently, XMRV has been detected in blood cells
of patients with chronic fatigue syndrome.

The aim of this study was to elucidate the
transmission routes and tissue tropism of XMRV by
comparing its host range, receptor usage and LTR
functionality with other MLV isolates.

We demonstrate using pseudotype experiments that
XMRV Env mediates efficient infection of cells from
different species.

We show that replication competent XMRV infects
various human cell types, including hematopoietic
cell lines and prostate stromal fibroblasts.


XMRV-LTR activity is significantly higher in the
prostate cancer cell line LNCaP and in prostate
stromal fibroblasts, compared to other cell types
tested and could be one factor contributing to
efficient viral spread in prostate tissue.




Copyright 2009 Elsevier Inc. All rights reserved.

PMID: 20110097 [PubMed - indexed for MEDLINE]







~~~~