Gluten & Gastrointestinal Symptoms -Without Celiac Disease

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>>>> 16 January 2011 <<<<
Editorship : j.van.roijen@chello.nl
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Because many ME/CFS patients suffer from *Irritable
Bowel Syndrome* (IBS), this article may be of
interest.



Personal experience:

After a strong positive H2S Urine Test [PROTEA
Biopharma - see Co-Cure: http://bit.ly/f71l6r],

a severe bowel-dysbiosis was found with a
overgrowth of H2S and d/l lactate-producing bacteria.
Also found were several intolerances: gluten,
fructose and lactose.

Immediately after the gluten-, fructose-, lactose-free
diet, I became very sick with high fever and
night sweats; which was explained as detoxification
symptoms.

I'm still busy with a long antibiotic cure.



~jan van roijen




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http://bit.ly/fqkJ7l


AJG

The American Journal of
GASTROENTEROLOGY




Colon/Small Bowel


(11 January 2011)

doi:10.1038/ajg.2010.487


Gluten Causes Gastrointestinal
Symptoms in Subjects Without Celiac
Disease: A Double-Blind Randomized
Placebo-Controlled Trial


Jessica R Biesiekierski, Evan D Newnham, Peter M
Irving, Jacqueline S Barrett, Melissa Haines,
James D Doecke, Susan J Shepherd, Jane G Muir
and Peter R Gibson



OBJECTIVES:

Despite increased prescription of a gluten-free diet
for gastrointestinal symptoms in individuals who do
not have celiac disease, there is minimal evidence
that suggests that gluten is a trigger.

The aims of this study were to determine whether
gluten ingestion can induce symptoms in non-celiac
individuals and to examine the mechanism.

METHODS:

A double-blind, randomized, placebo-controlled
rechallenge trial was undertaken in patients with
irritable bowel syndrome in whom celiac disease was
excluded and who were symptomatically controlled
on a gluten-free diet.

Participants received either gluten or placebo in the
form of two bread slices plus one muffin per day with
a gluten-free diet for up to 6 weeks.

Symptoms were evaluated using a visual analog
scale and markers of intestinal inflammation, injury,
and immune activation were monitored.



RESULTS:

A total of 34 patients (aged 29–59 years, 4 men)
completed the study as per protocol.

Overall, 56% had human leukocyte antigen
(HLA)-DQ2 and/or HLA-DQ8.

Adherence to diet and supplements was very high.

Of 19 patients (68%) in the gluten group, 13
reported that symptoms were not adequately
controlled compared with 6 of 15 (40%) on placebo
(P=0.0001; generalized estimating equation).

On a visual analog scale, patients were significantly
worse with gluten within 1 week for overall
symptoms (P=0.047), pain (P=0.016), bloating
(P=0.031), satisfaction with stool consistency
(P=0.024), and tiredness (P=0.001).

Anti-gliadin antibodies were not induced. There were
no significant changes in fecal lactoferrin, levels of
celiac antibodies, highly sensitive C-reactive protein,
or intestinal permeability.

There were no differences in any end point in
individuals with or without DQ2/DQ8.


CONCLUSIONS:

*Non-celiac gluten intolerance* may exist, but no
clues to the mechanism were elucidated.



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