XMRV -Host Range and Cellular Tropism

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>>>> 9 January 2011 <<<<
Editorship : j.van.roijen@chello.nl
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Host range and cellular tropism of the
human exogenous gammaretrovirus XMRV.


Stieler K, Schulz C, Lavanya M, Aepfelbacher M,
Stocking C, Fischer N.


Institute for Medical Microbiology and Virology,
University Medical Center Eppendorf, Martinistrasse
52, 20246 Hamburg, Germany.



Abstract


Recently, the first human infection with an
exogenous gammaretrovirus (XMRV) was reported.

In its initial description, XMRV was confined to
prostate stromal fibroblasts, although subsequent
reports demonstrated XMRV protein expression in
prostate epithelial cells.

Most recently, XMRV has been detected in blood cells
of patients with chronic fatigue syndrome.

The aim of this study was to elucidate the
transmission routes and tissue tropism of XMRV by
comparing its host range, receptor usage and LTR
functionality with other MLV isolates.

We demonstrate using pseudotype experiments that
XMRV Env mediates efficient infection of cells from
different species.

We show that replication competent XMRV infects
various human cell types, including hematopoietic
cell lines and prostate stromal fibroblasts.


XMRV-LTR activity is significantly higher in the
prostate cancer cell line LNCaP and in prostate
stromal fibroblasts, compared to other cell types
tested and could be one factor contributing to
efficient viral spread in prostate tissue.




Copyright 2009 Elsevier Inc. All rights reserved.

PMID: 20110097 [PubMed - indexed for MEDLINE]







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